Evaluation of elimination of chloramphenicol in shrimp (penaeus monodon) under experimental conditions using lc/ms/ms

The use of Chloramphenicol in shrimp product has been banned in the European Union (EU), the United States and even in Viet Nam.

SUMMARY
However, to control CAP absence in local farming still remain an open issue.Thus, research on elimination of CAP residues in
shrimp muscle (Penaeus monodon ) were conducted to help manager and farmer use antibiotics efficiently. Muscle residue depletion of CAP following oral administration was evaluated in shrimp under experimental conditions.

Four groups of shrimps were cultured in pond and fed a commercial medicated diet containing 2000 mg/kg. Sampling was conducted at different intervals (1, 5, 10, 20, 30, 60, 120 h) after the cossation of medication. Drug analysis was carried out by LC/MS/MS, and LOQ of method was 0,03 ng/g. The concentration of CAP after 60-h post-dosing are undetectable (<0,3 ng/g). So, it is not used in mucle residue depletion of CAP analysis. The elimination half-life (t1/2) of CAP was 13,5 h.

Source: Nguyễn Thanh Điền, Phùng Võ Cẩm Hồng